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Saturday September 5, 2015


Q: What is the acceptable ischemic time between procurement and re-implantation of donor lung to recipient body? (select one)


A) Less than 2 hours


B) Less than 4 hours


C) Less than 6 hours


D) Less than 8 hours


E) There is no time limit (as far as organ is good)




Answer: D


Recommended optimal acceptable ischemic time between procurement and re-implantation of donor lung to recipient body is up to 8 hours, though institutions may accept  ischemic times of up to 12 hours. Studies have shown that the risks of primary graft dysfunction and 30 day mortality increase with more than 8 hours of ischemia.





Reference:


1.  de Perrot M, Liu M, Waddell TK, Keshavjee S. Ischemia-reperfusion-induced lung injury. Am J Respir Crit Care Med 2003; 167:490. 


2. Thabut G, Mal H, Cerrina J, et al. Graft ischemic time and outcome of lung transplantation: a multicenter analysis. Am J Respir Crit Care Med 2005; 171:786.











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