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"CRITICAL CARE A DAY"
 
 

 
 
 
 
 
Sunday December 21, 2014

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Q: Leucocytosis is a known side effect of steroid treatment. What would be the best way to differentiate it from infection induced leucocytosis?


Answer: A left shift in total WBC count with more than 6 percent band forms is a good indicator of infection. Also, request can be made to lab to look for the appearance of toxic granulation which are rare in corticosteroid-induced leucocytosis.
 
 
Reference:
 
Shoenfeld Y, Gurewich Y, Gallant LA, Pinkhas - Prednisone-induced leukocytosis. Influence of dosage, method and duration of administration on the degree of leukocytosis.- J.Am J Med. 1981 Nov;71(5):773-8.
 






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